N-METHYL-2-PYRROLIDONE FOR PEPTIDE SYNTHESIS

50.00

 

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Technical Data Sheet, N-METHYL-2-PYRROLIDONE

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Description

Catalogue Number
Synonyms NMP, 1-Methylpyrrolidin-2-one, 1-Methyl-2-pyrrolidon, N-Methylpyrrolidone, N-Methylpyrrolidinone, Cas 872-50-4
Overview N-Methyl-2-pyrrolidone (NMP) is a polar aprotic solvent commonly used in peptide synthesis, particularly in solid-phase peptide synthesis (SPPS). It effectively dissolves both amino acids and coupling reagents, facilitating the activation and coupling of amino acid residues. Its high solvating power and stability make it ideal for promoting efficient peptide bond formation and resin swelling during synthesis.

Product Information

N-Methyl-2-pyrrolidone (NMP) is a high-purity raw material commonly used as a solvent in pharmaceutical and chemical manufacturing. As a polar aprotic liquid, it effectively dissolves a wide range of organic and inorganic compounds, making it ideal for processes like peptide synthesis. NMP is valued for its stability, low volatility, and strong solvating properties, which contribute to high reaction efficiency and product purity.
Formula C5H9NO
Molar mass (M) 99,133 g/mol
Density 1.028 g/cm³
Boiling point (bp) ~202 °C
Flash point 91 °C
Melting point -24 °C

Application(s)

Pharmaceutical Industry Solvent in solid-phase peptide synthesis (SPPS)
Reaction medium for drug formulation and active pharmaceutical ingredient (API) production
Electronics Used in the manufacture of lithium-ion batteries as a solvent for electrode binders
Employed in semiconductor cleaning and photoresist stripping
Polymers and Plastics Solvent for polyvinylidene fluoride (PVDF) and other high-performance polymers
Used in the production of polyimides and polyurethanes
Coatings and Paints Acts as a coalescing agent and solvent in paints, varnishes, and inks
Petrochemical and Chemical Processing Solvent in extraction processes, especially for aromatic hydrocarbons
Used in catalyst recovery and polymerization reactions
Agriculture Carrier solvent in some pesticide formulations due to its ability to dissolve both hydrophobic and hydrophilic substances
Cleaning and Degreasing Employed in industrial cleaners for removing resins, coatings, and adhesives

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Additional information

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2.5 L

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glass