Technical Data Sheet, Hexafluorisopropanol
Hexafluoroisopropanol (HFIP)
Hexafluoroisopropanol (HFIP) is a highly polar fluorinated alcohol commonly used in organic synthesis, polymer research, and pharmaceutical formulations. Its chemical formula is C₃H₂F₆O, and it is known for its strong hydrogen bonding properties and acidity compared to typical alcohols.
Product Information
Hexafluoroisopropanol (HFIP) is a highly polar, fluorinated alcohol used as a solvent in peptide synthesis, polymer science, and organic reactions. It dissolves tough polymers like polyamides, disaggregates proteins, and stabilizes reactive intermediates. HFIP is also valued in NMR and drug formulation due to its strong hydrogen bonding and easy volatility.
| Appearance | Clear, colorless liquid |
| Boiling Point | ~58–60 °C |
| Melting Point | ~–4 °C |
| Density | ~1.6 g/cm³ at 20 °C |
| Solubility | Miscible with water and solvents |
| pKa (acidity) | ~9.3 (acidic for an alcohol) |
| Vapor Pressure | High (volatile) |
| Odor | Sharp, alcohol-like |
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Hexafluoroisopropanol (HFIP) Safety Data Sheet (MSDS)
| Hazard Pictogram(s) |
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| Hazard Statement(s) |
H302 – Harmful if swallowed. H312 – Harmful in contact with skin. H314 – Causes severe skin burns and eye damage. H318 – Causes serious eye damage. H332 – Harmful if inhaled. H335 – May cause respiratory irritation. H361 – Suspected of damaging fertility or the unborn child. H373 – May cause damage to central nervous system through prolonged exposure. |
| Precautionary Statement(s) |
Prevention: Use only in a chemical fume hood. Wear protective gloves, eye protection, and lab coat. Avoid breathing vapors or mist. Wash hands and skin thoroughly after handling. Response: Skin Contact: Rinse with water for 15+ minutes. Remove contaminated clothing. Eye Contact: Flush eyes for 15+ minutes. Seek immediate medical attention. Inhalation: Move to fresh air. If symptoms persist, get medical help. Ingestion: Do not induce vomiting. Rinse mouth. Contact a poison center or doctor. |
| Signal Word | Danger |
| Storage class | 6.1B Toxic substances |
| WGKs | WGK 1 – slightly hazardous to water |
| Disposal | Dispose of as hazardous chemical waste according to local regulations. |
First Aid Measures for HFIP Exposure
| Inhalation | Move victim to fresh air immediately. Seek emergency help if symptoms develop. |
| Skin Exposure | Remove contaminated clothing and rinse skin under running water for at least 15 minutes. |
| Eye Contact | Irrigate eyes with water continuously and consult an ophthalmologist. |
| Ingestion | Do not induce vomiting. Administer water if conscious and get immediate medical help. |
Transport & Regulatory Information - CAS 920-66-1
| UN Number | 3265 |
| Proper Shipping Name | Corrosive liquid, acidic, organic, n.o.s. (Hexafluoroisopropanol) |
| Hazard Class | 8 (Corrosive) |
| Packing Group | I or II |
| Compliance | DOT, IATA, IMDG compliant with proper labeling and documentation |
