Technical Data Sheet, N-METHYL-2-PYRROLIDONE
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Description
| Catalogue Number | |
| Synonyms | NMP, 1-Methylpyrrolidin-2-one, 1-Methyl-2-pyrrolidon, N-Methylpyrrolidone, N-Methylpyrrolidinone, Cas 872-50-4 |
| Overview | N-Methyl-2-pyrrolidone (NMP) is a polar aprotic solvent commonly used in peptide synthesis, particularly in solid-phase peptide synthesis (SPPS). It effectively dissolves both amino acids and coupling reagents, facilitating the activation and coupling of amino acid residues. Its high solvating power and stability make it ideal for promoting efficient peptide bond formation and resin swelling during synthesis. |
Product Information
N-Methyl-2-pyrrolidone (NMP) is a high-purity raw material commonly used as a solvent in pharmaceutical and chemical manufacturing. As a polar aprotic liquid, it effectively dissolves a wide range of organic and inorganic compounds, making it ideal for processes like peptide synthesis. NMP is valued for its stability, low volatility, and strong solvating properties, which contribute to high reaction efficiency and product purity.
| Formula | C5H9NO |
| Molar mass (M) | 99,133 g/mol |
| Density | 1.028 g/cm³ |
| Boiling point (bp) | ~202 °C |
| Flash point | 91 °C |
| Melting point | -24 °C |
Application(s)
| Pharmaceutical Industry |
Solvent in solid-phase peptide synthesis (SPPS) Reaction medium for drug formulation and active pharmaceutical ingredient (API) production |
| Electronics |
Used in the manufacture of lithium-ion batteries as a solvent for electrode binders Employed in semiconductor cleaning and photoresist stripping |
| Polymers and Plastics |
Solvent for polyvinylidene fluoride (PVDF) and other high-performance polymers Used in the production of polyimides and polyurethanes |
| Coatings and Paints | Acts as a coalescing agent and solvent in paints, varnishes, and inks |
| Petrochemical and Chemical Processing |
Solvent in extraction processes, especially for aromatic hydrocarbons Used in catalyst recovery and polymerization reactions |
| Agriculture | Carrier solvent in some pesticide formulations due to its ability to dissolve both hydrophobic and hydrophilic substances |
| Cleaning and Degreasing | Employed in industrial cleaners for removing resins, coatings, and adhesives |
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